Endocrine Abstracts

Introduction: Celiac disease (CD) is a common condition in children with type 1 diabetes (T1D). This condition is often asymptomatic and predisposes to severe complications of diabetes. The aim of this work was to study the clinical, biological, and evolutionary features of CD in diabetic children compared to a control group of non-celiac diabetic children.Patients and methods: Retrospective study of a cohort of 10 T1D children with CD compared to a cont...

Introduction: Langerhans cell histiocytosis (LCH) is a rare disease characterized by non-specific granulomatous deposits in many tissues. The hypothalamic-pituitary region is infiltrated in 5 to 50% of patients with LCH but most often in those with the multifocal form. Diabetes insipidus (DI), the most common hormonal abnormality, occurs in 15–50% of patients. Anterior pituitary deficiency occurs only in 5 to 20% of patients. We report the case of a patient with LCH who h...

Introduction: Short stature is a common manifestation of Noonan Syndrome (NS) that affects up to 70% of patients with this syndrome. We present 2 observations of NS associated with growth hormone (GH) deficiency.Observations: Case 1: A 7-year-old female patient was admitted for a growth delay (height at −4 SD and weight at -1 SD). On examination, she had a dysmorphic syndrome suggestive of NS: triangular face, hypertelorism, low-implanted ears, a w...

Introduction: Known to be ‘male Turner syndrome’, Noonan syndrome (NS) classically associates short stature, facial dysmorphism, and congenital heart disease. It is an autosomal dominant disease with an incidence of 1: 1,000 to 1: 2,500. We report 3 observations of NS.Observations: Case 1: A 7-year-old female patient was admitted for a growth delay. On examination, she had a dysmorphic syndrome suggestive of NS: facial dysmorphism with triangul...